diazepam raises toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. Modify Therapy/Keep an eye on Closely. Scientific tests have demonstrated that The mix of benzodiazepines and buprenorphine altered the usual ceiling effect on buprenorphine-induced respiratory despair, creating the respiratory consequences of buprenorphine sh

Sustained repetitive firing seems confined by benzodiazepines' result of slowing recovery of sodium channels from inactivation.[one hundred ten]Reserve concomitant prescribing of such medicines in sufferers for whom other cure options are insufficient. Limit dosages and durations to the minimum amount demanded. Keep an eye on intently for signs of